A Wearable Electrochemical Sensing System for Non-Invasive Monitoring of Lithium Drug in Bipolar Disorder

Lithium represents the main drug for treatment of Bipolar Disorder (BD) as it acts a mood stabilizer. However, because its narrow therapeutic window, psychiatric patients are obliged to frequent tests in hospital control their lithium blood concentration during therapy. In this paper, we fabricate first time complete non-invasive system Therapeutic Drug Monitoring (TDM) sweat people suffering from BD. The wearable electrochemical sensing platform includes paper fluidics and stable Reference Electrode (RE). detection is based on use potentiometric Ion-Selective (ISE) with nanostructured solid contact order increase potential stability sensor. A chemical chlorination combined PVC membrane doped an Ionic Liquid (IL) used minimize possible drifts RE. Nernstian response (56.8±3.9 mV /decade) range clinical interest then proved aqueous solution sweat. integration transporting fresh sample area also considered. already tested collected reservoir made slow adsorbing paper. successfully simulated setup by using mannequin. measured well compared predicted ones window drug, proving good capability artificial